<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0"><channel><title><![CDATA[Geneovese, Inc.]]></title><description><![CDATA[Targeting cancer with a next-generation ADC platform designed to improve precision and reduce off-target toxicity.]]></description><link>https://www.geneovese.com/blog</link><generator>RSS for Node</generator><lastBuildDate>Wed, 02 Sep 2026 12:08:54 GMT</lastBuildDate><atom:link href="https://www.geneovese.com/blog-feed.xml" rel="self" type="application/rss+xml"/><item><title><![CDATA[Linker Remnants, Lysosomal Trapping and Why Clean Payload Release Matters]]></title><description><![CDATA[Oftentimes antibody drug conjugates have an enzymatically cleavable linker region that, upon cleavage, will release the drug within the targeted cell. Post-cleavage, the payload needs to be released ‘cleanly’ as a free drug, without any linker remnants attached.  If the free drug is not released, then it has a higher likelihood of being trapped inside the lysosome and being degraded.  Escaping the lysosome is based on the free drugs hydrophobicity, lipophilicity and size of the payload, as...]]></description><link>https://www.geneovese.com/post/linker-remnants-lysosomal-trapping-and-why-clean-payload-release-matters</link><guid isPermaLink="false">6a8f6f34748dc98ea45ed487</guid><category><![CDATA[Perspectives]]></category><pubDate>Wed, 26 Aug 2026 23:21:05 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/11062b_672ac73a405a416193f1821de06ad1c6~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>Janet Little</dc:creator></item><item><title><![CDATA[Is IC50 Measuring Cytotoxicity or Growth Inhibition in vitro?]]></title><description><![CDATA[Short answer: The IC50 can measure both; it is context-dependent.  Whether or not the IC50 is reflecting a 50% Cytotoxicity or a 50% Growth Inhibition largely depends on what readout reagent is being utilized. IC50 is ambiguous because it’s an effect-measurement: the question is, what is the IC50 measuring an effect of? The most common readout reagents I’ve seen are Celltiter Glo, which measures ATP indicative of cell viability and cellular proliferation, and Caspase 3/7, which measures the...]]></description><link>https://www.geneovese.com/post/is-ic50-measuring-cytotoxicity-or-growth-inhibition-in-vitro</link><guid isPermaLink="false">6a8f67f6a6bf65007ed289e6</guid><category><![CDATA[Perspectives]]></category><pubDate>Wed, 26 Aug 2026 22:29:44 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/f50dcf24d67c409782a99c6872192433.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>Janet Little</dc:creator></item><item><title><![CDATA[How to Install Your Own Local, Private, Offline AI Onto Your Laptop for Free]]></title><description><![CDATA[The following instructions utilize open-source code as it is designed to be used. Using local AI ensures that you own the AI conversation data, because it never leaves your machine.  Make AI work for you and keep you IP safe by default. Here are the steps for installing your own personal, private and free AI on your laptop: Go to the Llama.cpp page (on github) here: https://llama.app/ Download Llama.cpp Download the version of the specific open-source AI model you want to run Some good recent...]]></description><link>https://www.geneovese.com/post/how-to-install-your-own-local-private-offline-ai-onto-your-laptop-for-free</link><guid isPermaLink="false">6a8e1412836b1f3da5f951b7</guid><category><![CDATA[Perspectives]]></category><pubDate>Tue, 25 Aug 2026 23:29:08 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/11062b_82aa9af9b33a49ffada7c6eb39a2d723~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>Janet Little</dc:creator></item></channel></rss>